12/4/2023 0 Comments Ionic activation bypass key freeRecent efforts also showed that diabetes-associated changes in signaling pathways and transcriptional factors contribute to the downregulation of BK channel expression. It is well established that the downregulation of vascular BK channel function with reduced BK channel protein expression and altered intrinsic BK channel biophysical properties is associated with diabetic vasculopathy. Large conductance Ca 2+-activated K + (BK) channels are abundantly expressed in arteries and are the key ionic determinant of vascular tone and organ perfusion.
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